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1.
World J Gastroenterol ; 24(6): 671-679, 2018 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-29456406

RESUMO

AIM: To compare health-related quality of life (HRQoL), anxiety, depression, and impulsivity scores in patients with and without carcinoid syndrome (CS), and correlated them with serum 5-hydroxyindoleacetic acid (5-HIAA) levels. METHODS: Patients with advanced gastroenteropancreatic neuroendocrine tumours (GEPNET), with and without CS completed HRQoL QLQ-C30 and QLQ-GI.NET21, Hospital Anxiety and Depression Scale (HADS) and Barratt Impulsivity Scale (BIS) questionnaires. Two-sample Wilcoxon test was applied to assess differences in serum 5-HIAA levels, two-sample Mann-Whitney U test for HRQoL and BIS, and proportion test for HADS, between those with and without CS. RESULTS: Fifty patients were included; 25 each with and without CS. Median 5-HIAA in patients with and without CS was 367nmol/L and 86nmol/L, respectively (P = 0.003). Scores related to endocrine symptoms were significantly higher amongst patients with CS (P = 0.04) and scores for disease-related worries approached significance in the group without CS, but no other statistically-significant differences were reported between patients with and without CS in responses on QLQ-C30 or QLQ-GI.NET21. Fifteen patients (26%) scored ≥ 8/21 on anxiety scale, and 6 (12%) scored ≥ 8/21 on depression scale. There was no difference in median 5-HIAA between those scoring < or ≥ 8/21 on anxiety scale (P = 0.53). There were no statistically significant differences between groups in first or second-order factors (BIS) or total sum (P = 0.23). CONCLUSION: Excepting endocrine symptoms, there were no significant differences in HRQoL, anxiety, depression or impulsivity between patients with advanced GEPNET, with or without CS. Over one quarter of patients had high anxiety scores, unrelated to peripheral serotonin metabolism.


Assuntos
Ansiedade/epidemiologia , Depressão/epidemiologia , Comportamento Impulsivo , Neoplasias Intestinais/psicologia , Síndrome do Carcinoide Maligno/psicologia , Tumores Neuroendócrinos/psicologia , Neoplasias Pancreáticas/psicologia , Qualidade de Vida , Neoplasias Gástricas/psicologia , Idoso , Ansiedade/sangue , Ansiedade/psicologia , Biomarcadores/sangue , Cromogranina A/sangue , Depressão/sangue , Depressão/psicologia , Feminino , Humanos , Ácido Hidroxi-Indolacético/sangue , Ácido Hidroxi-Indolacético/metabolismo , Neoplasias Intestinais/sangue , Neoplasias Intestinais/patologia , Masculino , Síndrome do Carcinoide Maligno/sangue , Síndrome do Carcinoide Maligno/patologia , Pessoa de Meia-Idade , Tumores Neuroendócrinos/sangue , Tumores Neuroendócrinos/patologia , Neoplasias Pancreáticas/sangue , Neoplasias Pancreáticas/patologia , Questionário de Saúde do Paciente , Prevalência , Serotonina/metabolismo , Neoplasias Gástricas/sangue , Neoplasias Gástricas/patologia
2.
Eur J Obstet Gynecol Reprod Biol ; 203: 214-9, 2016 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-27343738

RESUMO

OBJECTIVE: To assess PGD outcome using FISH analysis in couples with a history of recurrent miscarriage associated with a parental carrier of reciprocal translocation. STUDY DESIGN: Couples in whom one partner was a carrier of a reciprocal translocation and had a history of two or more miscarriages and a low risk of a live born offspring with an unbalanced chromosomal rearrangement, underwent PGD treatment between 2000 and 2012. RESULTS: 91 couples started 171 fresh and 11 frozen PGD cycles. Of the fresh cycles, 162 (95%) reached oocyte retrieval and 107 (63%) had embryo transfer. In 14 cycles (8%), surplus embryos were cryopreserved. Pregnancy was achieved in 52 fresh PGD cycles, leading to 20 miscarriages and 32 live births. Eleven frozen embryo transfer cycles resulted in two miscarriages and three live births. The overall live birth rate was 19% per fresh and frozen PGD cycle started (35/182) and miscarriage rate was 39% per pregnancy (22/57). The cumulative live birth rate was 32% per couple (29/91). CONCLUSION: After PGD for recurrent miscarriage in low-risk reciprocal translocation carriers, the miscarriage risk remains high and chance of live birth is low. For those translocation carriers, natural conception may be a better option.


Assuntos
Aborto Habitual/genética , Diagnóstico Pré-Implantação , Translocação Genética , Coeficiente de Natalidade , Transferência Embrionária , Feminino , Testes Genéticos , Humanos , Hibridização in Situ Fluorescente , Nascido Vivo , Masculino , Gravidez , Resultado da Gravidez , Taxa de Gravidez , Estudos Retrospectivos
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